Statin Intolerance and Suboptimal Statin Therapy
نویسندگان
چکیده
منابع مشابه
Insights Into Statin Intolerance
Stephen Kopecky, MD, FACC, FACP; Seth Baum, MD, FACC, FACPM, FAHA, FNLA; JoAnne M. Foody, MD, FACC, FAHA; Michael Koren, MD, FACC; James McKenney, PharmD, FNLA; Laurence Sperling, MD, FACC, FAHA, FACP; Nathan D. Wong, PhD, MPH, FACC, FAHA; Statin Intolerance Roundtable Participants Division of Cardiovascular Diseases (Kopecky), Mayo Clinic, Rochester, Minnesota; Women’s Preventive Cardiology Ce...
متن کاملMolecular mechanisms of statin intolerance
Statins reduce cardiovascular morbidity and mortality in primary and secondary prevention. Despite their efficacy, many persons are unable to tolerate statins due to adverse events such as hepatotoxicity and myalgia/myopathy. In the case of most patients, it seems that mild-to-moderate abnormalities in liver and muscle enzymes are not serious adverse effects and do not outweigh the benefits of ...
متن کاملStatin discontinuation and intolerance: the challenge of lifelong therapy.
Lifelong Therapy Statins are among the most widely prescribed drugs. They reduce atherosclerotic cardiovascular disease events and improve survival in patients with established disease. Recommendations virtually mandate statin use in secondary prevention and widely advocate use for primary prevention. Clinicians initiate statin therapy with the expectation that the patient will continue lifelon...
متن کاملStatin Intolerance: the Clinician’s Perspective
Muscle problems and other adverse symptoms associated with statin use are frequent reasons for non-adherence and discontinuation of statin therapy, which results in inadequate control of hyperlipidemia and increased cardiovascular risk. However, most patients who experience adverse symptoms during statin use are able to tolerate at least some degree of statin therapy. Given the profound cardiov...
متن کاملAlternate-Day Statin Therapy
In a previous article, I discussed adverse drug reactions (ADRs) attributed to statin therapy, specifically myopathies, as well as potential consequences and recommended alternatives. These ADRs are not trivial because they may lead to patient harm in severe cases and/or significant patient nonadherence in most cases. In fact, statins are frequently discontinued as a result of ADRs1,2 and for a...
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ژورنال
عنوان ژورنال: Journal of Atherosclerosis and Thrombosis
سال: 2019
ISSN: 1340-3478,1880-3873
DOI: 10.5551/jat.ed106